Six new and three synthetically known glycosides have been isolated from the leaves of Moringa oleifera, employing a bioassay-directed isolation method on the ethanolic extract. Most of these compounds are very rare in nature. Thiocarbamates showed strong hypotensive activity.
This article provides an up-today overview of this research area and discusses the role of PPARδ in the heart in light of the complex mechanisms of its transcriptional regulation and its potential as a translatable therapeutic target for the treatment of cardiac disorders.
Hypotensive activity of the ethanolic and aqueous extracts of Moringa oleifera whole pods and their parts, namely, coat, pulp, and seed was investigated. Thiocarbamate and isothiocyanate glycosides are the hypotensive principles of the pods and leaves of Moringa oleifera.
This study shows that the administration of Moringa Oleifera seed powder has a beneficial effect on the cardiac structure and function in hypertensive rats associated with an upregulation of PPAR-α and δ signaling. Moringa Oleifera treatment did not modify blood pressure in spontaneous hypertensive rats (SHR) but reduced nocturnal heart rate and improved cardiac diastolic function (reduction of isovolumetric relaxation time and deceleration time of the E wave, increase of ejection volume and cardiac output compared to nontreated SHR).
This study shows that ethanolic extracts of Moringa oleifera leaves resulted in the isolation of four pure compounds, niazinin A (1), niazinin B (2), niazimicin (3) and niaziminin A + B (4 + 5). Intravenous administration of either one of the compounds (1–10 mg/kg) produced hypotensive and bradycardiac effects.
Findings suggest that Moringa oliefera aqueous leaf extract contribute towards the pathophysiological regulation of weight gain and inflammation associated with high-fat-induced-obesity through gut bacteria modulation among other health benefits.

Moringa is an anti-hypertensive agent, it reduces high blood pressure